Lemeco Miller was the workhorse for the Bulldogs (1-1) for the second straight game, carrying 25 times for 123 yards and two touchdowns, including 22 rushes for 112 yards and two scores in the first half.
But a 38-yard touchdown pass to Willie Gibson, followed by a blocked punt that Gibson ran back for a touchdown and then an interception by the Bulldogs, their second of the first half, turned the tide in favor of the visitors.
Reed Gurchiek finished just 2-of-11 passing for 40 yards and the two picks for CU. Patriots quarterback Jay Bright was 8-of-16 for 116 yards and one score.
Cumberland begins division action next Saturday, hosting Belhaven University at 1:30 p.m.